Publications

2010s

Hines, J. P.; Smith, A. T.; Jacob, J. P.; Lukat-Rodgers, G. S.; Barr, I.; Rodgers, K. R.; Guo, F.; Burstyn, J. N. "CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity". J. Biol. Inorg. Chem. 2016. 21, 1021. PDF
 
Bowman, H.E.; Dent, M.R.; Burstyn, J.N. "Met104 is the CO-replaceable Ligand at Fe(II) Heme in the CO-sensing Transcription Factor BxRcoM-1" J. Biol. Inorg. Chem. 2016. 21, 1-11. PDF
 
Tanimura, N.; Miller, E.; Igarashi, K.; Yang, D.; Burstyn, J.N.; Dewey, C.N.; Bresnick, E.H. "Mechanism Governing Heme Synthesis Reveals a GATA Factor/Heme Circuit that Controls Differentiation". EMBO Reports. 2016. 17, 249-265. PDF

Smith, A.T.; Pazicni, S.; Marvin, K.A.; Stevens, D.J.; Paulsen, K.M.; Bursty, J.N. "Functional DIvergence of Heme-Thiolate Proteins: A Classification Based on Spectroscopic Attributes". Chemical Reviews. 2015, 115(7), 2532-2558. PDF

Su, Y.; Majtan, T.; Freeman, K.M.; Linck, R.C.; Ponter, S.; Kraus, J.P.; Burstyn, J.N. "Comparative Study of Enzyme Activity and Heme Reactivity in Drosophila melanogaster and Homo sapiens Cystathionine beta-Synthases." Biochemistry. 2013, 52(4), 741-751. PDF

Smith, A.T.; Marvin, K.A.; Freeman, K.M.; Kerby, R.L.; Roberts, G.P.; Burstyn, J.N. "Identification of Cys94 as the Distal Ligand to the Fe(III) Heme in the Transcriptional Regulator RcoM-2 from Burkholderia xenovorans". J. Biol. Inorg. Chem. 2012, 17, 1071-1082. PDF

Smith, A.T.; Su, Y.; Stevens, D.J.; Majtan, T.; Kraus, J.P.; Burstyn, J.N. "Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of Human Cystathionine ß-Synthase". Biochemistry. 2012, 51 (32), pp 6360–6370. PDF

Santiago Cintrón, M.; Green, O.; Burstyn, J.N. "Ethylene Sensing by Silver(I) Salt-Impregnated Luminescent Films". Inorg. Chem. 2012, 51 (5), 2737–2746. PDF

Barr, I.; Smith, A. T.; Chen, Y.; Senturia, R.; Burstyn, J. N.; Guo, F. "Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing." Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 1919-1924. PDF

Smith, A.T.; Majtan, T.;  Freeman, K.M.; Su, Y.; Kraus, J.P.; Burstyn, J.N. "Cobalt Cystathionine β-Synthase: A Cobalt-Substituted Heme Protein with a Unique Thiolate Ligation Motif". Inorg. Chem. 2011, 50, 4417-4427. PDF

Barr, I.; Smith, A.T.; Senturia, R.; Chen, Y.; Burstyn, J.N.; Guo, F. "DiGeorge Critical Region 8 (DGCR8) Is a Double-Cysteine-Ligated Heme Protein". J. Biol. Chem. 2011, 286, 16716-16725. PDF

Majtan, T., Freeman, K. M., Smith, A. T., Burstyn, J. N., Kraus, J. P. "Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin" Arch. Biochem. Biophys., 2011, 508, 25-30. PDF

Ostrowski, A. D., Deakin, S. J, Azhar, B., Miller, T. W., Francoleon, N., Cherney, M. M., Lee, A., Burstyn, J. N., Fukuto, J. M., Megson, I. L., Ford, P. C. "Nitric Oxide Photogeneration from trans-Cr(cyclam)(ONO)2+ in a Reducing Environment. Activation of Soluble Guanylyl Cyclase and Arterial Vasorelaxation" J. Med. Chem., 2010, 53, 715-722. PDF

2000s

Miller, T. W., Cherney, M. M., Lee, A. J., Francoleon, N. E., Farmer, P. J., Bruce King, S., Hobbs, A. J., Miranda, K. M., Burstyn, J. N., Fukuto, J. M. "The effects of nitroxyl (HNO) on soluble guanylyl cyclase activity: Interactions at ferrous heme and cysteine thiols" J. Biol. Chem., 2009, 284, 21788-21796. PDF

Marvin, K. A., Reinking, J. L., Lee, A. J., Pardee, K., Krause, H. M., Burstyn, J. N. "Nuclear receptors Homo sapiens Rev-erb beta and Drosophila melanogaster E75 are thiolate-ligated heme proteins, which undergo redox-mediated ligand switching and bind CO and NO" Biochemistry, 2009, 48, 7056–7071. PDF

Green, O., Gandhi, B. A., Burstyn, J. N. "Photophysical Characteristics and Reactivity of Bis(2,9-di-tert-butyl-1,10-phenanthroline)Cu(I)" Inorg. Chem., 2009, 48, 5704–5714. PDF

Lee, A. J., Clark, R. W., Youn, H., Ponter, S., Burstyn, J. N. "Guanidine Hydrochloride-Induced Unfolding of the Three Heme Coordination States of the CO-Sensing Transcription Factor, CooA" Biochemistry, 2009, 48, 6585-6597. PDF

Tseng, T. A., Burstyn, J. N. "Synthesis and DNA Cleavage Activity of a Bifunctional Intercalator-Linked Copper(II) Macrocycle" Chem. Commun., 2008, 6209-6211. PDF

Marvin, K. A., Kerby, R. L., Youn, H., Roberts, G. P., Burstyn, J. N. "The CO-activated transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch" Biochemistry, 2008, 47, 9016-9028. PDF

Cherney, M. M., Pazicni, S., Frank, N., Marvin, K. A., Kraus, J. P., Burstyn, J. N. "Ferrous Human Cystathionine β-Synthase Loses Activity during Enzyme Assay Due to a Ligand Switch Process." Biochemistry, 2007, 46, 13199-13210. PDF

Gandhi, B. A., Green, O., Burstyn, J. N. "Facile Oxidation-Based Synthesis of Sterically Encumbered Four-Coordinate Bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) and Related Three-Coordinate Copper(I) Complexes." Inorganic Chemistry 2007, 46, 3816-3825. PDF

Clark,R. W., Youn, H., Lee, A. J., Roberts, G. P., Burstyn, J. N. "DNA binding by an imidazole-sensing CooA variant is dependent on the heme redox state." Journal of Biological Inorganic Chemistry 2007, 12, 139-146. PDF

Pinkert, J. C., Clark, R. W., Burstyn, J. N. "Modeling proline ligation in the heme-dependent CO sensor, CooA, using molecule analogs." Journal of Biological Inorganic Chemistry 2006, 11, 642-650. PDF

Clark, R. W., Lanz, N. D., Lee, A. J., Kerby, R. L., Roberts, G. P., Burstyn, J. N. "Unexpected NO-dependent DNA binding by the CooA homolog from Carboxydothermus hydrogenoformans." Proceedings of the National Academy of Sciences USA, 2006, 103, 891-896. PDF

Pazicni, S., Cherney, M. M., Lukat-Rogers, G. S., Oliveriusová, J., Rodgers, K. R., Kraus, J. P., Burstyn, J. N. "The Heme of Cystathionine β-synthase Likely Undergoes a Thermally Induced Redox-Mediated Ligand Switch." Biochemistry, 2005, 44, 16785-16795. PDF

Pazicni, S., Lukat-Rodgers, G. S., Oliveriusová, J., Rees, K. A., Parks, R. B., Clark, R. W., Kraus, J., Rodgers, K. R., and Burstyn, J. N. "The redox behavior of the heme in cystathionine β-synthase is sensitive to pH." Biochemistry 2004, 43, 14684-14695. PDF

Clark, R. W., Youn, H., Parks, R. B., Cherney, M. M., Roberts, G. P., and Burstyn, J. N. "Investigation of the role of the N-terminal proline, the distal heme ligand in the CO sensor CooA." Biochemistry 2004, 43, 14149-14160. PDF

Green, O., Smith, N. A., Ellis, A. B., Burstyn, J. N. "AgBF4-Impregnated poly(vinyl phenyl ketone): An Ethylene Sensing Film." Journal of the American Chemical Society 2004, 126, 5952-5953. PDF

Youn, H., Kerby, R. L., Thorsteinsson, M. V., Clark, R. W., Burstyn, J. N., Roberts, G. P. "Analysis of the L116K Variant of CooA, the Heme-containing CO Sensor, Suggest the Presence of an Unusual Heme Ligation Resulting in Novel Activity." Journal of Biological Chemistry 2002, 277, 33616-33623. PDF

Amin, S., Chappell, L. L., Morrow, J. R., Tseng, T. A., Bodsgard, B. R., Burstyn, J. N. "Compounds of general interest. Preparation of a synthetic ribonuclease: the europium(III) complex of 1-(4-nitrobenzyl)-4,7,10-tris(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane." Inorganic Syntheses 2002, 33, 213-218. PDF

Carr, H. S., Tran, D., Reynolds, M. F., Burstyn, J. N., Spiro, T. G. "Activation of soluble guanylyl cyclase by four-coordinate metalloporphyrins: evidence for a role for porphyrin conformation." Biochemistry 2002, 41, 10149-10157. PDF

Deck, K. M., Tseng, T. A., Burstyn, J. N. "Triisopropyltriazacyclononane Copper(II): An Efficient Phosphodiester Hydrolysis Catalyst and DNA Cleavage Agent." Inorganic Chemistry 2002, 41, 669-677. PDF

Richter-Addo, G. B., Legzdins, P., Burstyn, J. "Introduction: Nitric Oxide Chemistry." Chemical Reviews 2002, 102, 857-860. PDF

Hirsch, J., DeBeer George, S., Solomon, E. I., Hedman, B., Hodgson, K. O., Burstyn, J. N. "Raman and Extended X-ray Absorption Fine Structure Characterization of a Sulfur-Ligated Cu(I) Ethylene Complex: Modeling the Proposed Ethylene Binding Site of Arabidopsis thaliana ETR1." Inorganic Chemistry 2001, 40, 2439-2441. PDF

Serfass, L., Carr, H. S., Aschenbrenner, L. M., Burstyn, J. N. "Calcium ion down regulates soluble guanylyl cyclase activity: Evidence for a second metal ion binding site." Archives of Biochemistry and Biophysics 2001, 387, 47-56. PDF

Bodsgard, B. R., Burstyn, J. N. "Silica-bound copper(II)triazacyclononane: a robust material for the heterogeneous hydrolysis of a phosphodiester." Chemical Communications 2001, 7, 647-648. PDF

Polzin, G. M., Burstyn, J. N. "Synthetic Cu(II) and Ni(II) peptidases," in Metal Ions in Biological Systems: Probing of Proteins by Metal Ions and Their Low-Molecular Weight Complexes, Vol. 38 (Astrid and Helmut Sigel, Eds.) 2000, pp. 103-143, Marcel Decker, New York.

Reynolds, M. F., Burstyn, J. N. "Mechanism of activation of soluble guanylyl cyclase by NO: allosteric regulation through changes in heme coordination geometry" in Nitric Oxide: Biology and Pathobiology (Louis Ignarro, Ed.) 2000, pp. 381-399, Academic Press, San Diego.

Ivanisevic, A., Reynolds, M. F., Burstyn, J. N., Ellis, A. B. "Photoluminescent Properties of Cadmium Selenide in Contact with Solutions and Films of Metalloporphyrins: Nitric Oxide Sensing and Evidence for the Aversion of an Analyte to a Buried Semiconductor-Film Interface" Journal of the American Chemical Society 2000, 122, 3731-3738. PDF

Reynolds, M. F., Parks, R. B., Burstyn, J. N., Shelver, D., Thorsteinsson, M. V., Kerby, R. L., Roberts, G. L., Vogel, K. M., Spiro, T. G. "Electronic absorption, EPR and resonance Raman spectroscopies of CooA, a CO-sensing transcription activator from R. rubrum, reveal a five-coordinate NO-heme." Biochemistry 2000, 39, 388-396. PDF

Kavana, M., Powell, D. R., Burstyn, J. N. "Static versus dynamic Jahn-Teller distortions in octahedral-like copper(II) complexes of 1,4,7-triazacyclononane and 1-oxa-4,7-diazacyclononane: implications for hydrolytic reactivity." Inorganica Chimica Acta 2000, 297, 351-361.

1990s

Vogel, K. M., Hu, S., Spiro, T. G., Dierks, E. A., Yu, A. E., Burstyn, J. N. "Variable forms of soluble guanylyl cyclase (sGC): protein ligand interactions and the issue of activation by CO." Journal of Biological Inorganic Chemistry 1999, 4, 804-813. PDF

Shelver, D., Thorsteinsson, M. V., Chung, S.-Y., Roberts, G. P., Reynolds, M. F., Parks, R. B., Burstyn, J. N. "Identification of two important heme site residues (Cys75 and His77) in CooA, the CO-Sensing transcription factor of Rhodospirillum rubrum." Biochemistry 1999, 38, 2669-2678. PDF

Hegg, E. L., Mortimore, S. H., Cheung, C.-L., Huyett, J. E., Powell, D. R., Burstyn, J. N. "Structure-reactivity studies in Cu(II)-catalyzed phosphodiester hydrolysis." Inorganic Chemistry 1999, 38, 2961-2968. PDF

Reynolds, M. F., Burstyn, J. N. "Nitric Oxide." McGraw Hill 1999 Yearbook of Science and Technology 1999, 255-256.

Hegg, E. L, Burstyn, J. N. "Toward the development of metal-based synthetic nucleases and proteases: a rationale and progress report in applying the principles of coordination chemistry." Coordination Chemistry Reviews 1998, 173, 133-165. PDF

Reynolds, M.F., Shelver, D., Kerby, R. L., Parks, R. B., Roberts, G. P., Burstyn, J. N. "EPR and Electronic Absorption Spectroscopies of the CO-sensing CooA Protein Reveal a Cysteine-Ligated Low-Spin Ferric Heme." Journal of the American Chemical Society 1998, 120, 9080-9081. PDF

Serfass, L., Burstyn, J. N. "Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity." Archives of Biochemistry and Biophysics 1998, 359, 8-16. PDF

Dierks, E. A., Burstyn, J. N. "Deactivation of soluble guanylyl cyclase by redox active agents." Archives of Biochemistry and Biophysics 1998, 351, 1-7. PDF

Hegg, E. L., Deal, K. A., Kiessling, L. L., Burstyn, J. N. "Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper(II) macrocycle Cu([9]aneN3)Cl2." Inorganic Chemistry 1997, 36, 1715-1718. PDF

Dierks, E. A., Hu, S., Yu, A.., Spiro, T. G., Burstyn, J. N. "Demonstration of the role of scission of the proximal histidine-iron bond in the activation of soluble guanylyl cyclase through metalloporphyrin substitution studies." Journal of the American Chemical Society 1997, 119, 7316-7323. PDF

Hegg, E. L., Burstyn, J. N. "Copper(II) macrocycles cleave single-stranded and double-stranded DNA under both aerobic and anaerobic conditions." Inorganic Chemistry 1996, 35, 7474-7481. PDF

Deal, K. A., Hengge, A. C., Burstyn, J. N. "Characterization of Transition States in Dichloro(1,4,7-triazacyclononane)copper(II)-Catalyzed Activated Phosphate Diester Hydrolysis." Journal of the American Chemical Society 1996, 118, 1713-1718. PDF

Deal, K. A., Burstyn, J. N. "Mechanistic studies of dichloro(1,4,7-triazacyclononane)copper(II)- catalyzed phosphate diester hydrolysis." Inorganic Chemistry 1996, 35, 2792-2798. PDF

Dierks, E. A., Burstyn, J. N. "Nitric oxide (NO·), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase." Biochemical Pharmacology 1996, 51, 1593-1600. PDF

Hegg, E. L., Burstyn, J. N. "Hydrolysis of Unactivated Peptide Bonds by a Macrocyclic Copper(II) Complex: Cu([9]aneN3)Cl2 Hydrolyzes Both Dipeptides and Proteins." Journal of the American Chemical Society 1995, 117, 7015-7016. PDF

Yu, A. E., Hawkins, B. K., Dierks, E. A.., Dawson, J. H., Burstyn, J. N. "Studies of the heme binding environment and ligand binding properties of soluble guanylyl cyclase: characterization of Fe(II)sGC and Fe(II)sGC(CO) by electronic absorption and magnetic circular dichroism spectroscopies and failure of CO to activate the enzyme." Biochemistry 1995, 34, 5896-5903. PDF

Kim, T. D., Burstyn, J. N. "Identification and partial purification of an endogenous regulator of soluble guanylyl cyclase from bovine lung." Journal of Biological Chemistry 1994, 269, 15540-15545. PDF

Yu, A. E., Hu, S., Spiro, T. G., Burstyn, J. N. "Resonance Raman Spectroscopy of Soluble Guanylyl Cyclase Reveals Displacement of Distal and Proximal Heme Ligands by NO." Journal of the American Chemical Society 1994, 116, 4117-4118. PDF

Burstyn, J. N., Deal, K. A. "Selective catalytic hydrolysis of a simple phosphodiester by a macrocyclic copper(II) complex." Inorganic Chemistry 1993, 32, 3585-3586. PDF