Hannah Bowman

Post-doctoral Scientist, Eli Lilly and Co. TS/MS E. coli platform API

Email: 
hbowman@chem.wisc.edu

Education

B.S. Chemistry, 2010, Purdue University
Study Abroad, 2009, Uppsala University, Uppsala, Sweden

Research Description

Hannah is a graduate student in the new Chemical Biology program and is interested in DNR, the dissimilative nitrate respiration regulator, from Pseudomonas aeruginosa. DNR is a transcription factor in the denitrification pathway of P. aeruginosa and previous work indicates that this protein possibly uses heme to sense NO which causes an allosteric change allowing DNR to bind to DNA.  However, only the apo-protein has been expressed and characterized to date. Hannah is also interested in RcoM, a CO-sensing transcription factor that has no solved structure. She is charaterizing various aspects of the protein to enhance our understanding of how the allosteric mechanism in RcoM may be similar/different from CooA.  Hannah is also interested in studying the structure of RcoM using many different techniques. Outside of the lab, Hannah spends her time sailing, playing kubb, practicing yoga, and birdwatching.

Publications

Bowman, H.E.; Dent, M.R.; Burstyn, J.N. "Met104 is the CO-Replacable Ligand at Fe(II) Heme in the CO-Sensing Transcription Factor BxRcoM-1" J. Biol. Inorg. Chem. 2016. 21(4), 559-569. DOI: 10.1007/s00775-016-1368-5

Conference Presentations

Bowman, H.E.; Burstyn J.N.; "Insights into the Structure of the Gas-Sensing Transcription Factor RcoM" Gordon Research Conference on Tetrapyrroles, July 20-24 2014, Salve Regina University, Newport, RI

Stevens, D.J.; Bowman, H.E.; Burstyn, J.N.; "Site-Directed Spin Labeling EPR Spectroscopy of the Transcription Factor CooA Reveals Multiple Conformational States" 246th ACS National Meeting, September 8-12, 2013, Indianapolis, IN; 2nd Annual CBI Career Development Conference, June 3-5, 2014, Madison, WI; 37th Steenbock Symposium, The Future of Chemical Biology, June 5-7, 2014, Madison, WI

Awards and Other Distinctions

College of Letters and Science Teaching Fellow Nominee (2013)

Outstanding Chemistry Teaching Award (2012)

Division of University Housing Honored Instructor (2011)